Review: Negative regulation of leptin receptor signalling.
نویسندگان
چکیده
Leptin was discovered as an adipostat, regulating body weight by balancing food intake and energy expenditure. Recently, leptin emerged as a pleiotropic cytokine. It plays a substantial role in a wide spectrum of other functions including immune regulation, bone formation and fertility. Leptin signalling is under tight control. Aberrations of this stringent control system may be implicated in a variety of pathologies. Here, we review the various mechanisms that control cellular leptin receptor signalling.
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ورودعنوان ژورنال:
- European cytokine network
دوره 17 3 شماره
صفحات -
تاریخ انتشار 2006